Morphometric analysis of craniofacial features in mono- and dizygotic twins discordant for unilateral cleft lip and palate
نویسندگان
چکیده
منابع مشابه
Morphometric analysis of craniofacial features in mono- and dizygotic twins discordant for unilateral cleft lip and palate.
OBJECTIVE To compare craniofacial differences between twins discordant for surgically repaired unilateral cleft lip and palate (CLP) during the developmental ages and to test the effect of zygosity on the shape and size of the craniofacial skeleton of the same twins by means of thin plate spline (TPS) analysis. MATERIALS AND METHODS Lateral and posteroanterior (PA) cephalometric films from 19...
متن کاملThree-dimensional craniofacial morphology in unilateral cleft lip and palate.
Craniofacial morphology and asymmetry were compared before, during, and after puberty within and between patients with unilateral complete cleft lip and palate (UCCLP) and a non-cleft group. In the UCCLP group, the posterior cranial base and total cranial base were significantly shorter at all skeletal periods, the maxilla was significantly retruded and posteriorly rotated, and the mandible was...
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Phenotypically discordant monozygotic twins offer the possibility of gene discovery through delineation of molecular abnormalities in one member of the twin pair. One proposed mechanism of discordance is postzygotically occurring genomic alterations resulting from mitotic recombination and other somatic changes. Detection of altered genomic fragments can reveal candidate gene loci that can be v...
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Monozygotic (MZ) twins may be discordant for complex traits due to differential environmental exposure in utero, epigenetic variability in imprinting, X chromosome inactivation, or stochastic effects. Occasionally MZ twins may be discordant for chromosomal and single gene disorders due to somatic mosaicism. For complex traits, which are due to the interactive effects of multiple genes and envir...
متن کاملCraniofacial morphology in children with operated complete unilateral cleft lip and palate.
The objective of the study was to compare the craniofacial characteristics of children with operated unilateral complete cleft lip and palate (UCLP) with those of noncleft children. Lateral and posteroanterior cephalometric radiographs of subjects with UCLP and controls who were matched for sex, age, and ethnic origin were analyzed and compared. There were a total of 21 subjects with UCLP (10 b...
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ژورنال
عنوان ژورنال: The Angle Orthodontist
سال: 2011
ISSN: 0003-3219,1945-7103
DOI: 10.2319/121710-725.1